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A strong synthetic opioid painkiller with a quick start and short half-life is fentanyl 100mcg patch, sometimes referred to as fentanyl. At the μ-opioid receptors, it has high agonistic activity. About 50–100 times as powerful as morphine is thought to be fentanyl.

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A fentanyl patch, sometimes referred to as fentanyl, is a strong synthetic opioid painkiller with a quick start and short half-life. At μ-opioid receptors, it has substantial agonist properties. It is thought that fentanyl has 50–100 times the potency of morphine.

Patch for fentanyl Fentanyl was first made available for palliative use in the mid-1990s in the form of a patch. Over the next ten years, other forms of the drug were also launched, including a lollipop, dissolving pills, and a sublingual spray that resorbs via the skin within the mouth. The most often used synthetic opioid in medicine as of 2012 was fentanyl. 1700 kg were utilized worldwide in 2013.

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There have been thousands of overdose deaths annually in recent years due to the recreational use of fentanyl. Erroneous medical usage has also led to fatalities. Under close observation, fentanyl can be a fairly safe surgical anesthetic due to its unusually large therapeutic index (270). Nevertheless, due to its extreme potency, precise measurements of highly diluted fentanyl in solution are necessary; attempting to measure a dose of pure fentanyl powder without the use of sophisticated scientific equipment is impractical because it would be difficult or impossible to distinguish between an effective and a lethal dose of the drug if they were placed next to each other.

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